Apolipoprotein B-containing lipoproteins and atherosclerotic cardiovascular disease [version 1; referees: 2 approved]

Apolipoprotein B-containing lipoproteins and atherosclerotic cardiovascular disease [version 1; referees: 2 approved]

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Cholesterol-rich, apolipoprotein B (apoB)-containing lipoproteins are now widely accepted as the most important causal agents of atherosclerotic cardiovascular disease.Multiple unequivocal and orthogonal lines of evidence all rockfleece converge on low-density lipoprotein and related particles as being the principal actors in the genesis of atherosclerosis.Here, we review the fundamental role of atherogenic apoB-containing lipoproteins in cardiovascular disease and several other humoral and parietal haralson apple tree for sale factors that are required to initiate and maintain arterial degeneration.The biology of foam cells and their interactions with high-density lipoproteins, including cholesterol efflux, are also briefly reviewed.